Brazilian side Chapecoense were on their way from Bolivia to Medellin International Airport in Colombia to play in the Copa Sudamerica final when the plane came down.
There were 72 passengers and nine crew on board, Colombian aviation officials said.
The commander of the Fire Department of La Union reported that at least ten people were being treated at the scene, according to mioriente.com, but Medellin airport authorities released a statement saying just 'six people may have survived'.
The crash site is only able to be reached by ground emergency services due to the steep terrain and low visibility, and is 30 minutes outside of the town of La Unión.
Local media outlets reported that the plane crashed at about 10.15pm on Monday night after suffering power failures while flying through the mountainous Antioquia Department.
Confronting images capture the exact moment the plane dropped from the radar.
It's understood that nearby hospitals have been placed on 'maximum alert' and are preparing for injured passengers to be treated.