When asked if he thinks Kanye's situation might have anything to do with a curse on the sister's male suitors , he said: "I actually thought about that, because at first it was a big joke to everybody.
"But in Africa there have always been sayings that sometimes you can't deny what you see, but oftentimes the eye may deceive you too. But in this case it's been not what you see, it's experiences.
"It's hard to comment on something like that as much as the evidence may show you that that's possible, you don't wanna discredit it as it may just be bad luck.
"I just wanna investigate this further just for fun, it is something to think about though. I wouldn't deny it but I wouldn't promote it either. When you think about it, the evidence all points to it."
Akon is now on the lookout to see if anything bad happens to Kim's half-sister Kylie Jenner's boyfriend Tyga.
He added to TMZ: "If something mental happens with Tyga then we can say it's safe to say as that's three in a row."
There have long been rumours of a so-called "Kardashian curse" after some of the men associated with the family's females fell on hard times.
Khloe's ex-husband Lamar Odom collapsed and almost died at a Nevada brothel last year after a drugs and alcohol binge.
And last November, Kourtney's former partner Scott Disick - who she has kids Mason, six, Penelope, four, and 23-month-old Reign with - spent a month in Cliffside Malibu rehab centre to get treatment with alcohol and other substance abuse issues.